A review of the Neurobiological Basis of Autism

Abstract: 

Michelle Hartley-McAndrew, MD;* Arie Weinstock, MD

This manuscript reviews ongoing developments in autism research that defines it as a behavioral phenotype with many known neurobiological and molecular causes. Strides in neuroimaging, histopathology, neurophysiology, genetics and metabolic disorders are discussed that support the understanding of autism as a pervasive abnormality of neural systems with particular dysfunction of neuronal connections that impacts the development of socialization, communication and behavior. The aim of this review is to provide insight into the current knowledge of the complex pathophysiology of autism.

Key Words: Autism, Seizures, Neurobiological basis, connectivity Autism, Seizures, Neurobiological basis, connectivity

Michelle Hartley-McAndrew, MD;1* Arie Weinstock, MD2
1 Women and Children’s Hospital of Buffalo, Buffalo, NY
2 State University of New York at Buffalo School of Medicine and Biomedical Sciences
*Corresponding Author: Department of Child Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences. Medical Director, Children’s Guild Autism Spectrum Disorder Center, Women and Children’s Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222. (Email: mhartley-mcandrew@kaleidahealth.org)

CONFLICT OF INTEREST
None.

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